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Updated: Feb 1, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022
Benefits and disadvantages of preoperative chemoradiotherapy for rectal cancer
Abstract:
Preoperative chemoradiotherapy for rectal cancer is now widely performed and has been validated by multiple randomized controlled trials to be oncologically effective. The most important benefit of chemoradiotherapy is reduction of local recurrence. Potential benefits include increased sphincter preservation in good responders, and further organ preservation by non-operative management in patients with complete clinical response. Oncological bene- fits are limited within the pelvis, and it does not improve overall survival. Inherent disad- vantages include long duration of overall treatment, poor anal function after sphincter-pres- ervation, increase of perineal wound complication after abdominoperineal resection, and short-term and long-term toxicity of radiotherapy. This review highlights on the current evidences of preoperative chemoradiotherapy for rectal cancer.
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