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Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
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Advances in aspirin-exacerbated respiratory disease (AERD)
Abstract:
Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of asthma, eosinophilic nasal polyposis and a hypersensitivity to all medications that inhibit the cyclo- oxygenase (COX) -1 enzyme. Clinical history and observed aspirin provocation test remains gold standard for diagnosis of AERD. AERD patients typically have more severe asthma with airflow limitation and greater requirement for high-dose corticosteroid therapies. Over- production of cysteinyl-leukotrienes (CysLTs) and prostaglandin D2 (PGD2) correlate with the pathogenetic features of AERD, suggesting the possible involvement of mast cell activation with innate type 2 immune response. Next breakthroughs in diagnosis and treatment have been expected in the nearest futures.
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