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Methods for Detecting Cough and Airway Inflammation in Mice

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Cough variant asthma.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|December 15, 2018

Summary

Cough variant asthma (CVA) is the leading cause of chronic cough in Japan. Early inhaled corticosteroid treatment can prevent CVA progression to classic asthma.

Area of Science:

Pulmonology
Allergy and Immunology

Background:

Cough variant asthma (CVA) is a distinct asthma phenotype characterized by chronic cough.
It is the most frequent cause of chronic cough (≥8 weeks) in Japan.
CVA shares features with classic asthma, including airway hyperresponsiveness and inflammation.

Purpose of the Study:

To review the diagnosis and management of CVA.
To highlight the importance of early intervention in CVA.

Main Methods:

Diagnostic criteria for CVA involve cough responsiveness to bronchodilators (beta-agonists).
Primary treatment involves long-term inhaled corticosteroids (ICS).

Main Results:

Early ICS treatment may prevent CVA progression to classic asthma.

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Gastroesophageal reflux disease (GERD) may coexist and require management in refractory cases.

Conclusions:

CVA requires prompt diagnosis and consistent management with ICS.
Addressing comorbidities like GERD is crucial for intractable CVA cases.