Eosinophilic otitis media and eosinophilic chronic -hinosinusitis

In Japan, eosinophilic inflammations of upper airway, eosinophilic otitis media(EOM) and eosinophilic chronic rhinosinusitis(ECRS), have been paid attention as intractable disease in recent years. The most common characteristic of EOM is the presence of highly viscous middle ear effusion enriched eosinophils, and EOM carries a high risk of hearing loss. That of ECRS is the nasal polyps with eosinophil dominant infiltration, and ECRS has a high risk of impairment of smell. In the case of the treatment of bronchial asthma, it is necessary to be careful for nasal symp- toms and aural symptoms, since EOM and ECRS were associated with bronchial asthma at high rates.