Related Experiment Video
Updated: Feb 1, 2026
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
Published on: May 30, 2020
Eosinophilic granulomatosis with polyangiitis (EGPA) and allergic bronchopulmonary mycosis (ABPM)
Abstract:
Eosinophilic granulomatosis with polyangiitis(EGPA) is characterized by ANCA-related small vessel vasculitis with granuloma formation and chronic eosinophilic airway inflammation including severe asthma and nasal polyposis. Allergic bronchopulmonary mycosis(ABPM) is characterized by asthma, central bronchiectasis, eosinophilic mucoid impaction, and fungal sensitization. The accurate diagnosis in early stages for these severe type of asthma is very important for good prognosis. Recent reports claimed that mepolizumab may be effective ad-on treatment for EGPA, and omalizumab is effective for ABPA.
Related Concept Videos
02:06Allergic Reactions
01:27Allergic Drug Reactions
01:10Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...