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Precision Medicine in Pediatric Cancer: Current Applications and Future Prospects

Atif A Ahmed1,2, Divya S Vundamati3, Midhat S Farooqi4,5

  • 1Departments of Pathology and Pediatric Hematology-Oncology, University of Missouri School of Medicine, Kansas City, MO 64108, USA. aahmed@cmh.edu.

High-Throughput
|December 16, 2018
PubMed

Insights

Precision oncology uses molecular diagnostics like next-generation sequencing (NGS) to tailor cancer treatments. This approach has significantly improved survival rates for pediatric patients with leukemia and solid tumors.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Diagnostics

Background:

  • Precision oncology is revolutionizing cancer care by analyzing individual tumor genetics.
  • Advances in molecular diagnostics enable personalized treatment strategies.
  • Next-generation sequencing (NGS) is crucial for understanding tumor variability.

Purpose of the Study:

  • To review the current state of precision oncology in pediatric cancer.
  • To highlight therapeutic opportunities identified through molecular profiling.
  • To discuss clinical applications of precision oncology in children.

Main Methods:

  • Review of current literature on pediatric precision oncology.
  • Analysis of molecular diagnostic techniques, particularly NGS.
  • Examination of clinical outcomes in pediatric cancer patients.

Main Results:

  • Pediatric tumors exhibit distinct genetic profiles compared to adult tumors.
  • NGS has enhanced the understanding and treatment of pediatric cancers.
  • Precision oncology has led to improved survival for pediatric leukemia and solid tumors.

Conclusions:

  • Precision oncology offers significant advancements in treating pediatric cancers.
  • Molecular diagnostics are key to identifying targeted therapies for children.
  • Further research and clinical application are vital for advancing pediatric cancer care.
Keywords:
actionable mutationsnext generation sequencingpediatric cancerprecision medicine

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