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Related Concept Videos

Cells and Secretions of the Pancreas01:16

Cells and Secretions of the Pancreas

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The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Pancreas01:19

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The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Related Experiment Video

Updated: Feb 1, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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Non-Coding RNA in Pancreas and β-Cell Development.

Wilson K M Wong1, Anja E Sørensen2, Mugdha V Joglekar3

  • 1NHMRC Clinical Trials Center, University of Sydney, Camperdown NSW 2050, Sydney, Australia. wilson.wong@ctc.usyd.edu.au.

Non-Coding RNA
|December 16, 2018
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) play crucial roles in the development and function of pancreatic islet and beta cells. This review highlights the dynamic regulation and functions of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in these cells.

Keywords:
circular RNAsfetal developmentislets of Langerhanslong intergenic non-coding RNAslong non-coding RNAsmicroRNAnon-coding RNAspancreaspiwi associated RNAssmall nucleolar RNAsα-cellβ-cell

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Related Experiment Videos

Last Updated: Feb 1, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Developmental Biology

Background:

  • Non-coding RNAs (ncRNAs) are critical regulators of gene expression.
  • Pancreatic islet and beta cells are vital for glucose homeostasis.
  • Understanding ncRNA roles in beta cell biology is essential for treating diabetes.

Purpose of the Study:

  • To review current knowledge on ncRNAs in islet and beta cell development, maturation, and function.
  • To highlight the specific roles of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs).
  • To discuss emerging findings from advanced sequencing technologies.

Main Methods:

  • Literature review of studies on ncRNAs in pancreatic development and function.
  • Analysis of miRNA and lncRNA expression patterns during beta cell development.
  • Integration of data from ultra-deep RNA sequencing studies.

Main Results:

  • Specific miRNAs are dynamically regulated during pancreas development, islet differentiation, and beta cell replication.
  • Long non-coding RNAs (lncRNAs) are increasingly identified as key regulators, often associated with beta cell super-enhancers.
  • Imprinted ncRNAs also contribute to pancreas development and beta cell function.

Conclusions:

  • ncRNAs, including miRNAs and lncRNAs, are significant regulators of beta cell development and function.
  • Further research into ncRNA mechanisms can reveal novel therapeutic targets for metabolic diseases.
  • The dynamic roles of ncRNAs underscore their importance in maintaining beta cell identity and function.