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Effect of Coenzyme Q10 Supplementation on Testosterone
1Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan. sabanihani@just.edu.jo.
Biomolecules
|December 16, 2018
Summary
Coenzyme Q10 (CoQ10) supplementation shows no significant effect on testosterone levels in human males. While not boosting testosterone directly, CoQ10 may protect against toxicant-induced reductions by neutralizing free radicals.
Area of Science:
- Endocrinology
- Reproductive Biology
- Nutritional Science
Background:
- Testosterone is a key hormone influencing male health and well-being.
- Coenzyme Q10 (CoQ10) plays a vital role in cellular energy production.
- Previous research suggests a potential link between CoQ10 and testosterone levels.
Purpose of the Study:
- To systematically review and summarize the scientific literature on the influence of CoQ10 supplementation on testosterone production in males.
- To evaluate the effects of CoQ10 on testosterone in both human and animal studies.
- To explore CoQ10's potential role in mitigating factors that negatively impact testosterone.
Main Methods:
- A systematic literature search was conducted across Scopus, PubMed, and Web of Science databases.
- Studies published from November 1978 to October 2018, focusing on "coenzyme Q10" and "testosterone", were included.
- Relevant articles were analyzed and discussed to provide a comprehensive overview.
Main Results:
- Studies on human males indicated no significant impact of CoQ10 supplementation on testosterone levels.
- Animal studies, excluding reproductive toxicity research, also did not demonstrate a positive effect of CoQ10 on testosterone.
- CoQ10 supplementation was observed to mitigate testosterone reduction caused by chemical reproductive toxicants, primarily through antioxidant mechanisms.
Conclusions:
- Current evidence suggests CoQ10 supplementation does not directly enhance testosterone levels in human males.
- CoQ10 may offer protective benefits against testosterone depletion induced by certain environmental or chemical factors.
- Further research is warranted to confirm these findings and elucidate the precise mechanisms involved.
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