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Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Chromatin Position Affects Gene Expression02:35

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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Related Experiment Video

Updated: Feb 1, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

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Parathyroid carcinoma.

Antonio Stefano Salcuni1, Filomena Cetani2, Vito Guarnieri3

  • 1Unit of Endocrinology, University of Cagliari, Cagliari, Italy.

Best Practice & Research. Clinical Endocrinology & Metabolism
|December 16, 2018
PubMed
Summary
This summary is machine-generated.

Parathyroid carcinoma (PC) is a rare, indolent cancer. Genetic mutations in the CDC73 gene are common, aiding in family screening and early detection of parathyroid lesions.

Keywords:
CDC73 geneHPT-JT syndromehypercalcemiaparathyroid carcinoma

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Area of Science:

  • Endocrinology
  • Oncology
  • Genetics

Background:

  • Parathyroid carcinoma (PC) is a rare endocrine malignancy with typically indolent behavior.
  • The exact etiology of PC remains unknown.
  • Somatic mutations in the CDC73 gene are found in up to 70% of PC patients, with germline mutations occurring in one-third.

Purpose of the Study:

  • To highlight the genetic basis of PC, particularly CDC73 gene mutations.
  • To discuss diagnostic clues and management strategies for PC.
  • To emphasize the importance of lifelong follow-up for PC patients.

Main Methods:

  • Review of existing literature on parathyroid carcinoma.
  • Analysis of genetic data related to CDC73 mutations in PC.
  • Correlation of clinical, biochemical, and imaging findings with diagnosis and prognosis.

Main Results:

  • Germline CDC73 mutations allow for identification of carriers among relatives and potential early detection of parathyroid lesions.
  • Diagnostic suspicion of PC should be raised by markedly elevated serum calcium and PTH, large parathyroid lesions, and evidence of kidney and bone damage.
  • Complete surgical resection is the primary curative treatment, though recurrences are common.

Conclusions:

  • PC is an indolent tumor with long survival, but complications from hypercalcemia often lead to mortality.
  • Management involves surgical debulking and medical treatment for hypercalcemia.
  • Lifelong patient follow-up is crucial for managing this rare cancer.