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White matter organization in developmental coordination disorder: A pilot study exploring the added value of
Christian Hyde1, Ian Fuelscher1, Peter G Enticott1
1Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Victoria, Australia.
Neuroimage. Clinical
|December 16, 2018
Summary
Developmental Coordination Disorder (DCD) is linked to white matter differences in sensorimotor tracts, specifically the superior longitudinal fasciculi (SLF). Advanced MRI techniques like CSD reveal these abnormalities better than DTI.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Radiology
Background:
- Developmental Coordination Disorder (DCD) is characterized by motor impairments.
- Previous research on white matter in DCD used Diffusion Tensor Imaging (DTI), limited by its inability to resolve complex fiber crossings.
Purpose of the Study:
- To investigate white matter organization in sensorimotor tracts of adults with DCD using Constrained Spherical Deconvolution (CSD).
- To compare CSD findings with traditional DTI to highlight methodological advantages.
Main Methods:
- High angular diffusion MRI was performed on 19 adults (7 with DCD, 12 controls).
- Tractography of corticospinal tracts (CST) and superior longitudinal fasciculi (SLF) was conducted using both CSD and DTI models.
- Microstructural properties, including apparent fibre density (AFD) and tract volume, were analyzed.
Main Results:
- Individuals with DCD showed significantly reduced mean AFD in the left SLF (large effect size) and a trend for decreased right SLF tract volume (medium-large effect size) based on the CSD model.
- No significant differences in SLF microstructure were detected using DTI.
- No differences in CST microstructure were found between groups with either method.
Conclusions:
- Motor impairments in DCD may be associated with white matter abnormalities in the superior longitudinal fasciculi.
- Constrained Spherical Deconvolution (CSD) offers superior sensitivity for detecting white matter alterations in DCD compared to DTI.
- This study underscores the utility of advanced diffusion MRI models for understanding the neurobiological underpinnings of DCD.
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