[Analgesic and anti-inflammatory efficacy of biarison. Clinical experimental studies (author's transl)]

The analgesic time-effect profile of 600 mg Biarison (clinical experimental number: RU 43-715) compared with 100 mg indometacin, placebo and a blank test was recorded for 12 healthy subjects as an intra-individual single-blind trial by means of electrical measurement of thresholds in the teeth. Biarison shows a powerful analgesic effect with a maximum increase of the threshold by 22.3 mA after 75 minutes. The maximum increase in mA with indometacin and placebo was 18 and 9 mA respectively. The differences are confirmed statistically. Under double blind conditions, no significant differences in antiphlogistic activity could be established between Biarison (900 mg/day) and indometacin (150 mg/day) with reference to the edema appearing after maxillary sinus operations.