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Updated: Aug 19, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
Intestinal and hepatobiliary disposition of drugs
1Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66103.
Abstract:
Biliary excretion of xenobiotics is a complex process involving uptake into liver, intracellular sequestration and/or biotransformation, and transport into bile. A description of liver morphology is included to aid in the understanding of how chemical and physiological factors affect hepatic uptake and biliary excretion. Data will be presented with morphine and nalorphine that illustrate how efficient the intestinal and hepatobiliary system is in clearing drugs from the body. However, enterohepatic circulation can interfere with these processes.
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