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Pyrosequencing for Microbial Identification and Characterization
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Microbial patterns in patients with histamine intolerance.

M Schink1, P C Konturek2, E Tietz1

  • 1First Department of Medicine, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen, Germany.

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
|December 16, 2018
PubMed
Summary
This summary is machine-generated.

Histamine intolerance is linked to gut dysbiosis, characterized by increased Proteobacteria and reduced Bifidobacteriaceae. Patients with histamine intolerance exhibit lower gut microbial diversity and elevated zonulin, indicating a compromised intestinal barrier.

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Area of Science:

  • Gastroenterology
  • Microbiology
  • Immunology

Background:

  • Histamine intolerance is a condition linked to impaired histamine breakdown, potentially involving gut dysbiosis.
  • Elevated histamine levels may stem from diamine oxidase (DAO) deficiency or altered gut microbiota.

Purpose of the Study:

  • To investigate the intestinal bacterial composition in patients with histamine intolerance (HIT).
  • To compare gut microbiota profiles between HIT patients, food hypersensitivity (FH) patients, food allergy (FA) patients, and healthy controls (HC).
  • To assess stool histamine, zonulin levels, and DAO serum activity in relation to gut microbiota.

Main Methods:

  • 16s rRNA sequencing was used to analyze bacterial composition in stool samples.
  • Blood tests measured total and food-specific immunoglobulin E, plasma histamine, and DAO serum activity.
  • Stool samples were analyzed for histamine and zonulin levels.

Main Results:

  • HIT patients showed significantly reduced alpha-diversity and elevated levels of Proteobacteria.
  • Abundance of Bifidobacteriaceae was significantly lower in HIT patients compared to controls.
  • HIT patients had elevated stool zonulin levels, suggesting intestinal barrier dysfunction.
  • Reduced abundances of Butyricimonas and Hespellia, and elevated Roseburia were noted in HIT patients.

Conclusions:

  • Histamine intolerance is associated with gut dysbiosis, characterized by specific bacterial alterations and reduced diversity.
  • Elevated stool zonulin in HIT patients indicates compromised intestinal barrier function.
  • These gut microbiome and barrier changes may contribute to the pathogenesis of histamine intolerance.