Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 1, 2026

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells
09:15

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells

Published on: October 20, 2022

2.8K

What's new in autoinflammation?

Seza Ozen1

  • 1Department of Pediatrics, Hacettepe University, Ankara, Turkey. sezaozen@gmail.com.

Pediatric Nephrology (Berlin, Germany)
|December 16, 2018
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A challenging case of limb autoamputation.

Rheumatology (Oxford, England)·2025
Same author

Differences and Similarities Between Children and Adults With Rhupus Syndrome.

International journal of rheumatic diseases·2025
Same author

Extreme Phenotypic Variation in Siblings with Identical Homozygous Mutations Causing ADA2 Deficiency: A Case Series

Turkish journal of haematology : official journal of Turkish Society of Haematology·2025
Same author

Assessing cognitive functions in non-neuropsychiatric childhood systemic lupus erythematosus: Cross-sectional study.

Journal of psychosomatic research·2025
Same author

Transition of patients with systemic lupus erythematosus from pediatric to adult-oriented rheumatology care.

Turkish journal of medical sciences·2024
Same author

Consensus on transition care for juvenile idiopathic arthritis: a Delphi study with youth, caregivers, and health professionals.

Pediatric rheumatology online journal·2024

Autoinflammatory diseases, including periodic fevers and vasculitis, involve innate immune system dysfunction. Understanding their mechanisms aids in diagnosing and treating complications like kidney amyloidosis with targeted biologics.

Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Background:

  • Autoinflammatory diseases illuminate innate immunity and inflammation.
  • Periodic fevers represent common autoinflammatory conditions.
  • Delayed diagnosis of these conditions can lead to secondary amyloidosis.

Purpose of the Study:

  • To present new classification criteria for common periodic fever syndromes.
  • To highlight recently identified autoinflammatory diseases associated with vasculitis.
  • To discuss the role of monogenic autoinflammatory diseases in vasculitis differential diagnosis.

Main Methods:

  • Review of autoinflammatory disease pathogenesis and classification.
  • Identification and characterization of STING-associated vasculopathy of infancy (SAVI) and ADA2 deficiency.
Keywords:
Autoinflammatory diseaseChildrenFamilial Mediterranean feverKidneysPeriodic fever syndromesSecondary amyloidosisVasculitides

Related Experiment Videos

Last Updated: Feb 1, 2026

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells
09:15

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells

Published on: October 20, 2022

2.8K
  • Analysis of secondary amyloidosis as a complication and its treatment.

    • Main Results:

    • New classification criteria for common periodic fevers are proposed.
    • SAVI and ADA2 deficiency are recognized as monogenic autoinflammatory vasculitides.
    • Targeted biologics are effective for managing secondary amyloidosis.

    Conclusions:

    • Autoinflammatory diseases offer insights into general inflammation and innate immunity.
    • Understanding monogenic autoinflammatory diseases can inform research into common diseases.
    • Early diagnosis and targeted therapies are crucial for managing autoinflammatory conditions and their complications.