Related Experiment Video
Updated: Feb 1, 2026
05:19
A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
845
Polymorphisms in XPC gene and risk for prostate cancer
Rahma Said1,2, Karim Bougatef3, Nouha Setti Boubaker1
1Laboratory of Protein Engineering and Bio-active Molecules, National Institute of Applied Science and Technology - University of Carthage, Tunis, Tunisia.
Molecular Biology Reports
|December 16, 2018
Summary
Certain DNA repair gene variations, like XPC PAT I/I, increase prostate cancer risk. Other XPC gene variants may offer protection, highlighting complex genetic links to prostate cancer susceptibility.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Single nucleotide polymorphisms (SNPs) in DNA repair genes, such as the XPC gene, can impair DNA repair capacity (DRC).
- Reduced DRC is linked to genetic instability and potentially increased susceptibility to prostate cancer (PC).
Purpose of the Study:
- To investigate the association between XPC Lys939Gln and XPC-PAT polymorphisms and prostate cancer risk in the Tunisian population.
- To correlate these genetic findings with clinical parameters and lifestyle factors in prostate cancer patients.
Main Methods:
- A case-control study design was employed.
- Genotyping for XPC Lys939Gln and XPC-PAT polymorphisms was performed.
- Statistical analyses, including linkage disequilibrium testing and odds ratio calculations, were conducted.
Main Results:
- The XPC Lys939Gln polymorphism showed no association with prostate cancer risk.
- The XPC PAT I/I genotype was significantly associated with a 3.83-fold increased risk of prostate cancer (p = 0.00006).
- Combined analysis revealed that individuals with (Lys/Gln + PAT D/D) genotypes were protected against prostate cancer. No significant associations were found between XPC polymorphisms and clinical or lifestyle factors.
Conclusions:
- The XPC PAT I/I genotype is a risk factor for prostate cancer in Tunisia.
- Specific combined genotypes of XPC Lys939Gln and XPC-PAT may confer protection against prostate cancer.
- XPC gene polymorphisms are not significantly associated with clinical parameters or lifestyle factors in prostate cancer patients.
Related Concept Videos
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
9.8K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.8K
01:12Relative Risk
2.1K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.1K
01:33Cancer-Critical Genes I: Proto-oncogenes
11.5K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.5K
01:05Single Nucleotide Polymorphisms-SNPs
18.3K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.3K
01:26Factors Affecting the Risk of Infection
13.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.5K
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
719
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
719