Triphenyltin(IV) acylhydrazone compounds: Synthesis, structure and bioactivity

Area of Science:

• Organometallic Chemistry
• Medicinal Chemistry
• Biochemistry

Background:

• Triphenyltin(IV) compounds are explored for their biological activities.
• Acylhydrazone derivatives offer diverse chemical properties.
• Understanding structure-activity relationships is crucial for drug development.

Purpose of the Study:

• To synthesize and characterize novel triphenyltin(IV) acylhydrazone compounds.
• To investigate the binding properties of these compounds with bovine serum albumin (BSA).
• To evaluate the cytotoxic activity of the synthesized compounds against human lung cancer cells.

Main Methods:

• Synthesis of four triphenyltin(IV) acylhydrazone compounds.
• Characterization using elemental analysis, IR, NMR, and MS.
• Crystal structure determination.
• In vitro bioassays to assess cytotoxicity and mechanism of action.

Main Results:

• Successful synthesis and characterization of four new triphenyltin(IV) acylhydrazone compounds.
• Crystal structures revealed four-coordinated tin atoms with pseudo-tetrahedral geometry.
• Compounds demonstrated strong binding to BSA and oxidized NADH, generating reactive oxygen species (ROS).
• The compounds exhibited superior cytotoxic activity against A549 lung cancer cells compared to cisplatin, with notable selectivity.

Conclusions:

• The synthesized triphenyltin(IV) acylhydrazone compounds possess significant cytotoxic potential against lung cancer.
• Their mechanism involves ROS generation and induction of apoptosis.
• These compounds represent promising candidates for further development as anticancer agents.