Related Experiment Video
Updated: Feb 1, 2026

Quantification of Immunostained Caspase-9 in Retinal Tissue
Published on: July 25, 2022
PHQ-9: One factor or two?
Luke Boothroyd1, David Dagnan2, Steven Muncer3
1Clinical Psychology, TEWV NHS Trust, Middlesbrough, United Kingdom.
The Patient Health Questionnaire (PHQ-9) is reliable and valid. Mokken scale analysis suggests a single factor model is most appropriate for the PHQ-9, supporting prior research.
Area of Science:
- Psychometrics
- Mental Health Assessment
- Scale Analysis
Background:
- The Patient Health Questionnaire (PHQ-9) is a widely used depression screening tool.
- Previous research suggests both one-factor and two-factor structures for the PHQ-9.
- The psychometric properties of the PHQ-9 have not been fully explored using Mokken scale analysis.
Purpose of the Study:
- To investigate the psychometric properties of the PHQ-9 using Mokken scale analysis.
- To compare the fit of one-factor and two-factor models for the PHQ-9.
- To determine the most appropriate factor structure for the PHQ-9.
Main Methods:
- Confirmatory Factor Analysis (CFA) was used to assess model fit.
- Mokken scale analysis was employed to evaluate the unidimensionality of the PHQ-9.
- Retrospective data from an NHS Trust was utilized for the analyses.
Main Results:
- Confirmatory Factor Analysis indicated a two-factor structure provided a significantly better fit.
- However, the factors identified in the CFA were highly correlated.
- Mokken scale analysis suggested that a single-factor model is viable for the PHQ-9.
Conclusions:
- The findings support recent research indicating a one-factor model is most appropriate for the PHQ-9.
- A single-factor structure may better represent the underlying construct of depression measured by the PHQ-9.
- Further psychometric investigation using Mokken analysis confirms the utility of the PHQ-9.
More Related Videos
09:38Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
Published on: June 26, 2019
08:38A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model
Published on: March 3, 2023
Related Concept Videos
Transcription Factors
Factors Affecting Solubility
Transcription Elongation Factors
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
Factors Affecting Drug Distribution: Miscellaneous Factors
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
Electrolytes: van't Hoff Factor
The colligative properties of a solution depend only on the number, not on the identity, of solute species dissolved. The concentration terms in the equations for various colligative properties (freezing point depression, boiling point elevation, osmotic pressure) pertain to all solute species present in the solution. Nonelectrolytes dissolve physically without dissociation or any other accompanying process. Each molecule that dissolves yields one...
Factors Affecting Protein-Drug Binding: Drug-Related Factors
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...