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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Colligative Properties of Electrolytes
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PHQ-9: One factor or two?

Luke Boothroyd1, David Dagnan2, Steven Muncer3

  • 1Clinical Psychology, TEWV NHS Trust, Middlesbrough, United Kingdom.

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|December 16, 2018
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Summary
This summary is machine-generated.

The Patient Health Questionnaire (PHQ-9) is reliable and valid. Mokken scale analysis suggests a single factor model is most appropriate for the PHQ-9, supporting prior research.

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Area of Science:

  • Psychometrics
  • Mental Health Assessment
  • Scale Analysis

Background:

  • The Patient Health Questionnaire (PHQ-9) is a widely used depression screening tool.
  • Previous research suggests both one-factor and two-factor structures for the PHQ-9.
  • The psychometric properties of the PHQ-9 have not been fully explored using Mokken scale analysis.

Purpose of the Study:

  • To investigate the psychometric properties of the PHQ-9 using Mokken scale analysis.
  • To compare the fit of one-factor and two-factor models for the PHQ-9.
  • To determine the most appropriate factor structure for the PHQ-9.

Main Methods:

  • Confirmatory Factor Analysis (CFA) was used to assess model fit.
  • Mokken scale analysis was employed to evaluate the unidimensionality of the PHQ-9.
  • Retrospective data from an NHS Trust was utilized for the analyses.

Main Results:

  • Confirmatory Factor Analysis indicated a two-factor structure provided a significantly better fit.
  • However, the factors identified in the CFA were highly correlated.
  • Mokken scale analysis suggested that a single-factor model is viable for the PHQ-9.

Conclusions:

  • The findings support recent research indicating a one-factor model is most appropriate for the PHQ-9.
  • A single-factor structure may better represent the underlying construct of depression measured by the PHQ-9.
  • Further psychometric investigation using Mokken analysis confirms the utility of the PHQ-9.