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Updated: Feb 1, 2026

A Capsule-Based Model for Immature Hard Tick Stages Infestation on Laboratory Mice
Published on: July 9, 2020
Novel hard capsule prepared by tilapia (Oreochromis niloticus) scale gelatin and konjac glucomannan:
Yaru Liu1, Bafang Li1, Kai Zhang1
1College of Food Science and Engineering, Ocean University of China, No.5, Yu Shan Road, Qingdao, Shandong Province, 266003, PR China.
Abstract:
A novel material for making capsules was prepared with tilapia scale gelatin and konjac glucomannan (KGM). Rheological behaviors of gelatin with KGM at different levels (0.1%, 0.15%, and 0.2%, w/w) were investigated. The highest values (P < 0.05) of gel strength (518.33 ± 6.17 g) and melting temperature (39.7 ± 0.11 °C) could be observed at the gelatin solution with 0.15% (w/w) KGM. The tensile strength (TS) and elongation at break (EAB) of the films increased with the increasing of KGM. The water contact angle was enhanced with the increasing of KGM, indicating the decrease of the film hydrophilicity. XRD and FTIR showed the interactions between gelatin and KGM. Gelatin solution with 0.15% KGM is suitable for preparing capsules. Drug dissolution test in vitro showed the shell rupture time is in range of 3-5 min, and 80% of the drugs were released within 10 min. Therefore, the composite materials made of tilapia scale gelatin and KGM can be utilized for hard capsules.
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