Related Experiment Video
Updated: Feb 1, 2026
08:57
Layered Alginate Constructs: A Platform for Co-culture of Heterogeneous Cell Populations
Published on: August 7, 2016
8.3K
Local and controlled release of tamoxifen from multi (layer-by-layer) alginate/chitosan complex systems
Miryam Criado-Gonzalez1, Mar Fernandez-Gutierrez2, Julio San Roman2
1Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), c/ Juan de la Cierva, 3, 28006 Madrid, Spain.
Carbohydrate Polymers
|December 17, 2018
Summary
Multilayer alginate/chitosan films offer controlled release of tamoxifen for breast cancer treatment. The drug delivery system
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Developing effective drug delivery systems is crucial for targeted cancer therapy.
- Polysaccharide-based films offer biocompatibility and tunable properties for drug encapsulation.
Purpose of the Study:
- To develop and characterize multilayer alginate/chitosan films for local and controlled release of tamoxifen (TMX).
- To investigate the influence of film architecture and drug loading on TMX delivery for breast cancer treatment.
Main Methods:
- Fabrication of multilayer alginate/chitosan films using spray-assisted layer-by-layer (LbL) technique.
- Incorporation of tamoxifen (TMX) into intermediate layers of the polysaccharide films.
- Characterization of film properties and drug release kinetics.
Main Results:
- Alginate/chitosan multilayer films demonstrated sustained and local release of tamoxifen.
- The number of bilayers and tamoxifen loading influenced drug release profiles.
- Film area also played a role in modulating the therapeutic effect.
Conclusions:
- Alginate/chitosan multilayer films are promising biomaterials for controlled tamoxifen delivery.
- The developed system allows for optimization of drug release and therapeutic efficacy.
- This approach holds potential for localized breast cancer treatment.
Related Concept Videos
01:21Layers of the Epidermis
8.2K
The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
8.2K
01:30Thematic Layering in GIS
351
In the past, planning projects such as schools or public facilities required extensive manual effort to gather and compile data. Information such as property boundaries, soil characteristics, road networks, zoning regulations, and flood zones had to be sourced individually from courthouses, utility providers, and registry offices. Assembling these datasets into a coherent format often took several months, delaying project timelines.The introduction of Geographic Information Systems (GIS)...
351
01:15Layers of the Heart Wall
5.6K
The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
5.6K
01:18Boundary Layer Characteristics
616
When a fluid encounters a solid surface, a boundary layer forms due to the interaction between the fluid's motion and the stationary surface. This phenomenon is characterized by a thin region adjacent to the surface where viscous forces dominate, influencing the fluid's velocity profile. The development of the boundary layer begins at the leading edge of the surface and evolves as the fluid moves downstream.As the fluid flows over the surface, friction between the fluid and the wall slows down...
616
01:11Thin-Layer Chromatography (TLC): Overview
4.7K
Thin-layer chromatography (TLC) is a chromatography technique that separates compounds based on their polarity. TLC typically uses polar silica gel, a form of silicon dioxide, as the stationary phase. The silica gel contains hydroxyl (OH) groups on its surface, which form hydrogen bonds with polar compounds, influencing their adhesion to the stationary phase.
To begin the analysis, a mixture of compounds is spotted on the starting line on the TLC plate using a thin capillary. The bottom of the...
To begin the analysis, a mixture of compounds is spotted on the starting line on the TLC plate using a thin capillary. The bottom of the...
4.7K
01:21Layers of Connective Tissue Proper
3.5K
Fascia, a thin layer of fibrous connective tissue, is distributed throughout the body. It demarcates and forms a supportive covering over skeletal muscles, bones, blood vessels, and organs. There are three main types of facia— superficial fascia, deep fascia, and subserous fascia. These are all present at different depths in the body. Fascia reduces the friction and permits muscles, joints, and organs to easily slide against each other, facilitating movement of the body and preventing...
3.5K