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Published on: August 10, 2017
The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target
Dipanjan Chanda1, Dietbert Neumann2, Jan F C Glatz3
1Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands; Current affiliation: Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Daegu, Republic of Korea.
Abstract:
The endocannabinoids anandamide (AEA) and 2-arachidonoylglyerol (2-AG) are endogenous lipid mediators that exert protective roles in pathophysiological conditions, including cardiovascular diseases. In this brief review, we provide a conceptual framework linking endocannabinoid signaling to the control of the cellular and molecular hallmarks, and categorize the key components of endocannabinoid signaling that may serve as targets for novel therapeutics. The emerging picture not only reinforces endocannabinoids as potent regulators of cellular metabolism but also reveals that endocannabinoid signaling is mechanistically more complex and diverse than originally thought.
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