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Recent preparative applications of redox enzymes
Christopher K Prier1, Birgit Kosjek1
1Merck & Co., Inc., Rahway, NJ, 07065, USA.
Current Opinion in Chemical Biology
|December 17, 2018
Summary
Redox enzymes enable efficient industrial chemical synthesis. Advances in enzyme discovery, protein engineering, and process engineering are accelerating biocatalysis adoption for sustainable manufacturing.
Area of Science:
- Biocatalysis and Enzyme Engineering
- Industrial Chemistry
- Sustainable Manufacturing
Background:
- Redox enzymes are crucial for efficient chemical synthesis.
- Industrial-scale production of chemicals relies on robust catalytic methods.
- Biocatalysis offers a sustainable alternative to traditional chemical synthesis.
Purpose of the Study:
- To survey recent preparative applications of redox enzymes in industrial synthesis.
- To highlight mature and emerging enzyme technologies for chemical production.
- To discuss the integration of enzyme engineering and process engineering for industrial biocatalysis.
Main Methods:
- Review of recent literature on redox enzyme applications.
- Analysis of commercial enzyme platforms and protein engineering strategies.
- Examination of process engineering considerations for enzymatic synthesis.
Main Results:
- Redox enzymes facilitate diverse chemical transformations for industrial needs.
- Protein engineering is often required to adapt enzymes for specific substrates and conditions.
- Successful industrial application necessitates balancing enzymatic capabilities with process engineering requirements.
Conclusions:
- A convergence of enzyme discovery, protein engineering, and process engineering drives biocatalysis adoption.
- These advancements are expected to accelerate the development and implementation of enzymatic synthetic processes.
- Biocatalysis is poised for wider industrial application in the near future.
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