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Updated: Feb 1, 2026

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
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Prognostic role of microRNA-155 expression in gliomas: A meta-analysis

Yan Zhou1, Xuan Wang1, Zhen Liu1

  • 1Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Clinical Neurology and Neurosurgery
|December 17, 2018
PubMed

Insights

MicroRNA-155 (miR-155) shows potential as a prognostic biomarker in glioma patients. Elevated miR-155 levels are associated with poorer overall survival, indicating its clinical relevance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Research

Background:

  • MicroRNA-155 (miR-155) is implicated in the clinical outcomes of various cancers.
  • The prognostic significance of miR-155 in glioma, a primary brain tumor, requires further clarification.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the prognostic value of miR-155 in glioma patient survival.
  • To determine if miR-155 can serve as a reliable biomarker for glioma prognosis.

Main Methods:

  • Meta-analysis of non-laboratory studies focusing on miR-155 and glioma overall survival (OS).
  • Pooled hazard ratios (HRs) using random or fixed effects models, assessed heterogeneity, performed subgroup and sensitivity analyses.
  • Publication bias evaluated using Begg's funnel plots and Egger's test.

Main Results:

  • Included 9 studies with 1259 glioma patients.
  • Elevated miR-155 was associated with significantly poorer OS in glioma patients (HR = 1.40, 95% CI [1.19-1.63], P < 0.001).
  • Heterogeneity was observed (I-squared = 52.4%, P = 0.032), necessitating further investigation.

Conclusions:

  • miR-155 may function as a promising prognostic biomarker for glioma.
  • Elevated miR-155 levels correlate with adverse survival outcomes in glioma patients.
  • Further clinical validation is warranted to establish miR-155 in glioma prognosis.
Keywords:
GliomasMeta-analysisMiR-155Prognosis

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