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Updated: Feb 1, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
No association between common genetic variation in FOXP2 and language impairment in schizophrenia
Nina S McCarthy1, Melanie L Clark2, Assen Jablensky2
1Division of Psychiatry, Centre for Clinical Research in Neuropsychiatry, Faculty of Health and Medical Sciences, The University of Western Australia, Medical Research Foundation Building, Perth WA 6000, Australia; Centre for the Genetic Origins of Health and Disease, Faculty of Health Sciences, Curtin University and Faculty of Health and Medical Sciences, The University of Western Australia, Medical Research Foundation Building, Perth WA 6000, Australia.
Abstract:
The FOXP2 gene is hypothesised to be involved in schizophrenia by affecting speech and language development. Associations between common single nucleotide polymorphisms (SNPs) in FOXP2 and language have been inconsistent. We tested five previously associated SNPs for association with language in the Western Australian Family Study of Schizophrenia (n = 709, including n = 333 with schizophrenia/spectrum disorder) and found no significant associations. When we included all common FOXP2 variants, one SNP (rs2189008) was nominally associated with language. This is the most comprehensive analysis to date and indicates that common variants in FOXP2 do not play a major role in speech and language development in a clinical family sample.
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