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Therapeutic targeting of angiogenesis molecular pathways in angiogenesis-dependent diseases

Asghar Fallah1, Ali Sadeghinia2, Houman Kahroba3

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 17, 2018
PubMed

Insights

Anti-angiogenic therapy targets blood vessel formation crucial for cancer and other diseases. This review covers strategies, clinical uses, challenges, and advances in targeted anti-angiogenesis treatments.

Area of Science:

  • Oncology
  • Ophthalmology
  • Vascular Biology

Background:

  • Angiogenesis, the formation of new blood vessels, is essential for tumor growth and metastasis in most human cancers.
  • Angiogenesis also plays a key role in other severe conditions like diabetic retinopathy and age-related macular degeneration.

Purpose of the Study:

  • To review current anti-angiogenic therapy strategies.
  • To discuss clinical applications of these therapies.
  • To highlight challenges and recent advancements in targeted anti-angiogenesis treatments.

Main Methods:

  • Literature review of anti-angiogenic therapies.
  • Analysis of clinical trial data and outcomes.
  • Examination of emerging targeted therapy approaches.

Main Results:

  • Anti-angiogenic therapies have shown efficacy in treating various angiogenesis-dependent diseases.
  • Significant challenges remain, including resistance and toxicity.
  • Targeted therapies represent a promising frontier for improving treatment outcomes.

Conclusions:

  • Anti-angiogenic therapy is a vital treatment modality for cancer and other angiogenesis-related diseases.
  • Continued research into targeted approaches is crucial for overcoming current limitations and enhancing therapeutic effectiveness.
Keywords:
Angiogenesis-dependent diseasesAnti-angiogenesisAnti-angiogenic therapeuticsCancerVEGF–VEGFR system receptors

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