Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

513
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
513
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

986
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
986
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

2.1K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
2.1K
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

830
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
830
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

496
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
496
Endoscopic Studies II: Thoracocentesis01:26

Endoscopic Studies II: Thoracocentesis

1.4K
Thoracentesis(Thoracocentesis), commonly known as pleural tap, is a medical procedure where a 22 gauge needle is inserted into the pleural space, the area between the lung and chest wall. This procedure is commonly performed to diagnose or treat various respiratory disorders.
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence and risk factor of stricture after endoscopic submucosal dissection in the duodenal bulb.

Gastrointestinal endoscopy·2026
Same author

Endoscopic Submucosal Dissection Including the Minor Papilla for a Duodenal Laterally Spreading Tumor.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society·2026
Same author

Predictors of local recurrence and piecemeal resection in duodenal underwater endoscopic mucosal resection.

iGIE : innovation, investigation and insights·2026
Same authorSame journal

Prospective validation of magnified endoscopic examination with image-enhanced endoscopy as an optical biopsy for differentiating superficial duodenal epithelial tumor and non-neoplastic lesion in duodenum.

Digestion·2026
Same author

Use of rebamipide solution as a submucosal injection material to prevent esophageal stricture after endoscopic submucosal dissection: Animal study.

Endoscopy international open·2026
Same author

Real-World Evaluation of Remimazolam for Sedation During Gastrointestinal Endoscopy: Efficacy, Safety, and Risk Factors.

JGH open : an open access journal of gastroenterology and hepatology·2026

Related Experiment Video

Updated: Feb 1, 2026

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
05:57

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

8.9K

Endoscopic Submucosal Dissection in Patients with Ulcerative Colitis.

Satoshi Kinoshita1,2, Toshihiro Nishizawa1,2, Naohisa Yahagi2

  • 1Department of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.

Digestion
|December 17, 2018
PubMed
Summary

Patients with ulcerative colitis face higher colorectal cancer risks. Endoscopic submucosal dissection (ESD) offers a feasible option for removing dysplasia, despite technical challenges from fibrosis.

Keywords:
Endoscopic submucosal dissectionNeoplasmsUlcerative colitis

More Related Videos

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

1.5K
Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

32.7K

Related Experiment Videos

Last Updated: Feb 1, 2026

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
05:57

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

8.9K
Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

1.5K
Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

32.7K

Area of Science:

  • Gastroenterology
  • Endoscopic Surgery
  • Oncology

Background:

  • Ulcerative colitis (UC) patients have an elevated risk of colorectal cancer, with risk increasing significantly over time.
  • Current guidelines recommend endoscopic surveillance and resection of dysplasia in UC patients.
  • Submucosal fibrosis in UC can complicate endoscopic treatments like endoscopic mucosal resection (EMR).

Purpose of the Study:

  • To evaluate the feasibility and technical considerations of endoscopic submucosal dissection (ESD) for circumscribed dysplasia in ulcerative colitis.
  • To compare the efficacy and risks of ESD versus EMR in the context of colitic mucosa and submucosal fibrosis.

Main Methods:

  • Review of existing studies on endoscopic resection techniques for dysplasia in ulcerative colitis.
  • Analysis of the technical challenges posed by submucosal fibrosis during ESD.
  • Comparison of ESD outcomes with EMR in similar patient populations.

Main Results:

  • Endoscopic submucosal dissection (ESD) is a feasible technique for resecting circumscribed dysplasia in ulcerative colitis patients.
  • ESD can achieve complete en bloc resection, overcoming limitations of EMR caused by submucosal fibrosis.
  • While ESD carries risks like perforation and bleeding, it can potentially avoid surgery.

Conclusions:

  • Endoscopic submucosal dissection (ESD) is a viable alternative for managing dysplasia in ulcerative colitis, especially when fibrosis is present.
  • Expert endoscopists using appropriate equipment are crucial for successful and safe ESD in this challenging patient group.
  • ESD offers a way to avert surgery by enabling complete resection of dysplasia in ulcerative colitis.