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Related Experiment Videos

Hypoglycaemia in severe falciparum malaria.

B S Das1, S K Satpathy, D Mohanty

  • 1Rourkela Steel Plant, Ispat General Hospital, Orissa, India.

Transactions of the Royal Society of Tropical Medicine and Hygiene
|January 1, 1988
PubMed
Summary

Severe malaria patients on quinine may develop hypoglycemia. Careful monitoring of plasma glucose is crucial during quinine therapy to prevent dangerously low blood sugar levels.

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Area of Science:

  • Clinical Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Severe Plasmodium falciparum malaria is a life-threatening condition.
  • Quinine is a primary treatment for malaria but can have side effects.

Purpose of the Study:

  • To assess the incidence of hypoglycemia in severe malaria patients.
  • To investigate the role of quinine in causing hypoglycemia.

Main Methods:

  • Studied 46 patients with severe P. falciparum malaria.
  • Measured plasma glucose and insulin levels before, during, and after quinine treatment.

Main Results:

  • Hypoglycemia occurred in 5 patients, with one pregnant patient reaching 0.67 mmol/litre.
  • Most patients showed a significant decrease in plasma glucose and an increase in plasma insulin after quinine.

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  • A strong correlation (r=0.79) was observed between glucose and insulin changes.

    • Conclusions:

    • Patients with severe malaria, especially those treated with quinine, require close monitoring for hypoglycemia.
    • Quinine therapy may contribute to hypoglycemia in severe malaria cases.