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Strategies for Study of Neuroprotection from Cold-preconditioning
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Targeting mast cell as a neuroprotective strategy.

Umut Ocak1, Pinar Eser Ocak1, Annie Wang2

  • 1a Department of Basic Sciences, Division of Physiology , Loma Linda University School of Medicine , Loma Linda , CA , USA.

Brain Injury
|December 18, 2018
PubMed
Summary

Mast cells (MCs) contribute to brain damage after injury by disrupting the blood-brain barrier and causing neuroinflammation. Targeting MC activation offers a potential neuroprotective strategy for acute brain injury management.

Keywords:
Mast cellbrainneuroinflammationneuroprotectionstroketrauma; hypoxia

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Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • Mast cells (MCs) are immune cells found near blood vessels in the brain.
  • Evidence suggests MC activation contributes to blood-brain barrier disruption, neuroinflammation, and neurodegeneration.

Purpose of the Study:

  • To review the harmful effects of MCs in various brain injuries.
  • To explore therapeutic strategies targeting MC activation for neuroprotection, especially in acute phases.

Main Methods:

  • Extensive literature search conducted on Pubmed/Central in March 2018.
  • Comprehensive summary of MC activation effects in acute brain injury.
  • Review of current pharmacological strategies targeting MC activation.

Main Results:

  • MC activation and degranulation significantly worsen acute pathology in diverse brain injuries.
  • Injuries include focal/global cerebral ischemia, intracerebral hemorrhage, subarachnoid hemorrhage, and TBI.
  • Brain MCs are key contributors to acute pathological processes post-brain injury.

Conclusions:

  • Brain MCs play a significant role in acute pathological processes following brain injury.
  • Targeting brain MCs presents a novel therapeutic avenue for neuroprotection.