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Updated: Feb 1, 2026
08:01
Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
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[Invasive aspergillosis in critically ill patients]
Paula Ramírez1, José Garnacho-Montero2
1Servicio de Medicina Intensiva, Hospital Universitario y Politécnico La Fe, Valencia, España.
Revista Iberoamericana De Micologia
|December 18, 2018
Summary
Invasive aspergillosis (IA) is an emerging threat in critically ill patients. Early diagnosis using galactomannan testing and prompt treatment with isavuconazole offer promising outcomes.
Area of Science:
- Critical care medicine
- Infectious diseases
- Pulmonology
Background:
- Invasive aspergillosis (IA) is an emergent pathology in critically ill patients without severe immunosuppression.
- Risk factors include chronic corticosteroid use, COPD, and liver cirrhosis.
- Diagnosis is challenging due to non-specific symptoms and limited diagnostic test sensitivity.
Purpose of the Study:
- To review the diagnostic and therapeutic strategies for invasive aspergillosis in critically ill patients.
- To highlight the utility of specific diagnostic algorithms and biomarkers.
- To evaluate antifungal treatment options, including newer agents.
Main Methods:
- Review of diagnostic algorithms adapted for critically ill patients.
- Emphasis on Aspergillus isolation from respiratory specimens.
- Assessment of galactomannan determination in bronchoalveolar lavage fluid.
- Evaluation of antifungal agents: voriconazole, amphotericin B, and isavuconazole.
Main Results:
- Diagnostic algorithms incorporating Aspergillus isolation are efficient.
- Galactomannan testing in bronchoalveolar lavage fluid is a key diagnostic tool.
- Voriconazole and amphotericin B are established treatments but have adverse effects.
- Isavuconazole demonstrates high efficacy and safety, presenting a valuable alternative.
Conclusions:
- Prompt diagnosis and treatment are crucial for invasive aspergillosis in the ICU.
- Galactomannan testing aids in early detection.
- Isavuconazole is a promising and well-tolerated treatment option for critically ill patients.
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