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Related biomarkers of neurocognitive impairment in children with obstructive sleep apnea

Yewen Shi1, Huanan Luo1, Haiqin Liu1

  • 1Department of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, No.157, Xiwu Road, Xi'an, 710004, Shaanxi, China.

International Journal of Pediatric Otorhinolaryngology
|December 18, 2018
PubMed

Insights

Biomarkers like plasma insulin growth factor-1 (IGF-1) and Alzheimer's disease (AD)-related markers show promise in identifying neurocognitive impairment in children with obstructive sleep apnea (OSA). Further research is needed to confirm their effectiveness.

Area of Science:

  • Pediatric Sleep Medicine
  • Neuroscience
  • Biomarker Research

Background:

  • Obstructive sleep apnea (OSA) in children is linked to neurocognitive and behavioral deficits.
  • Identifying reliable biomarkers for these deficits is crucial for early intervention.

Purpose of the Study:

  • To review and categorize potential biomarkers for neurocognitive impairment associated with pediatric OSA.
  • To assess the utility of various markers in identifying cognitive deficits in children with OSA.

Main Methods:

  • A scoping review of studies evaluating biomarkers in children with OSA.
  • Categorization of biomarkers by research method: brain imaging, serological indicators, and urine markers.

Main Results:

  • Plasma insulin growth factor-1 (IGF-1) and Alzheimer's disease (AD)-related biomarkers show potential in distinguishing between children with and without neurocognitive impairment.
  • Brain imaging studies and urinary neurotransmitters may also aid in screening for cognitive issues in pediatric OSA.

Conclusions:

  • Limited research methods in children hinder the study of OSA-related cognitive susceptibility.
  • Multi-center prospective studies are essential to identify biomarkers for timely prediction and intervention of neurocognitive impairment in pediatric OSA.
Abstract

Keywords:
BiomarkersChildrenNeurocognitive impairmentObstructive sleep apnea

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