Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Self-Presentation01:25

Self-Presentation

322
Self-presentation is a fundamental aspect of social interaction, shaping both how others perceive individuals and how they view themselves. This dynamic process influences behaviors in various social settings, often leading people to adjust their appearance, speech, and demeanor to align with their desired identity. While self-presentation can be deliberate or unconscious, it plays a critical role in interpersonal relationships and self-perception.Forms of Self-PresentationSelf-presentation can...
322
Self-Presentation: Self-Monitoring and Self-Handicapping02:05

Self-Presentation: Self-Monitoring and Self-Handicapping

44.7K
People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
44.7K
Strategies of Self-Presentation I: Strategic Self-Presentation01:12

Strategies of Self-Presentation I: Strategic Self-Presentation

217
Strategic self-presentation refers to individuals' intentional efforts to influence how others perceive them. This process is employed in various social and professional settings, such as job interviews, dating, politics, and legal contexts, where individuals seek to shape impressions to gain social or material advantages. While people generally present themselves in ways that align with their authentic characteristics, external factors, such as cognitive load, can hinder their ability to...
217
Processes of Self-Presentation01:29

Processes of Self-Presentation

249
Effective self-presentation is a central component of social interaction and identity construction. It relies on the dynamic processes of defining the situation and engaging in self-disclosure. These mechanisms help individuals navigate social context expectations and manage how others perceive them, fostering mutual understanding and relationship development.Defining the SituationSocial situations are shaped by collectively understood frames—a set of widely understood rules or...
249
Strategies of Self-Presentation II: Self-Verification01:17

Strategies of Self-Presentation II: Self-Verification

190
Self-verification is a fundamental psychological drive wherein individuals seek affirmation of their self-concept from others, striving for consistency between their internal self-view and external perceptions. This drive operates even when the self-concept is negative, influencing interpersonal behavior and feedback preferences in complex and often counterintuitive ways. Unlike the self-enhancement motive, which seeks positive evaluations, self-verification prioritizes coherence and...
190
Autoimmune Disorders01:29

Autoimmune Disorders

1.7K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High K<sup>+</sup> intake alleviates experimental autoimmune encephalomyelitis (EAE) and increases T regulatory cells.

Cellular immunology·2022
Same author

NFAT5 contributes to the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and decrease of T regulatory cells in female mice.

Cellular immunology·2022
Same author

CD8+ T cells: The past and future of immune regulation.

Cellular immunology·2020
Same author

A novel CNS-homing peptide for targeting neuroinflammatory lesions in experimental autoimmune encephalomyelitis.

Molecular and cellular probes·2020
Same author

Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells.

Journal of autoimmunity·2018
Same author

Progression of experimental autoimmune encephalomyelitis is associated with up-regulation of major sodium transporters in the mouse kidney cortex under a normal salt diet.

Cellular immunology·2017

Related Experiment Video

Updated: Feb 1, 2026

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
18:08

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation

Published on: December 31, 2007

10.4K

Targeting antigen presentation in autoimmunity.

Jason R Lees1

  • 1Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

Cellular Immunology
|December 18, 2018
PubMed
Summary
This summary is machine-generated.

Targeting antigen presentation to CD4+ T cells offers a novel therapeutic strategy for autoimmune diseases. This approach focuses on modulating T cell activation by targeting antigen presentation, distinct from current T cell-intrinsic treatments.

Keywords:
Antigen presentationAutoimmunityImmune regulationInflammation

More Related Videos

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

9.2K
Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
06:57

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

9.6K

Related Experiment Videos

Last Updated: Feb 1, 2026

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
18:08

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation

Published on: December 31, 2007

10.4K
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

9.2K
Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
06:57

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

9.6K

Area of Science:

  • Immunology
  • Autoimmune Diseases
  • Therapeutic Strategies

Background:

  • Autoimmune diseases are complex disorders with significant societal impact.
  • CD4+ T cells are key players in the development and progression of autoimmune conditions.
  • Current treatments often focus on T cell-intrinsic activities.

Purpose of the Study:

  • To review therapeutic approaches targeting antigen presentation to CD4+ T cells in autoimmune diseases.
  • To explore the role of antigen modulation in existing and novel treatments.
  • To consider challenges associated with antigen-specific targeting.

Main Methods:

  • Review of current and potential therapeutic strategies.
  • Analysis of antigen presentation as a therapeutic checkpoint.
  • Consideration of antigen modulation in treatment modalities.

Main Results:

  • Antigen presentation to CD4+ T cells is a critical checkpoint for autoimmune responses.
  • Targeting antigen presentation offers an alternative to T cell-intrinsic therapies.
  • New antigen-targeted modalities show promise for autoimmune treatment.

Conclusions:

  • Modulating antigen presentation represents a promising therapeutic avenue for autoimmune diseases.
  • Antigen-specific targeting requires careful consideration of potential challenges.
  • This approach complements existing treatments by focusing on a distinct regulatory mechanism.