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Updated: Feb 1, 2026

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
[Methotrexate induced crystalline nephropathy: A rare histological finding on renal biopsy]
Prudence Colpart1, Sophie Félix1
1Service d'anatomie et cytologie pathologiques, centre hospitalier universitaire de Besançon, 3, boulevard Alexandre-Fleming, 25030 Besançon cedex, France.
Abstract:
Drug-induced crystalline nephropathies are secondary to abnormal accumulation of crystals leading to parenchymal renal injuries. Methotrexate, used to treat a wide range of malignancies, is one of the various drugs accountable in this particular condition. We report a case of acute renal injury during the course of high-dose methotrexate therapy in a patient presenting primary cerebral diffuse large B-cell lymphoma. Interestingly, the kidney biopsy revealed intratubular methotrexate crystal formations. We also summarize the distinctive characteristics of main crystalline nephropathies in order to guide pathologists toward the many types of crystals encountered on renal biopsy.
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