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Microparticles from Endothelial Cells and Immune Cells in Patients with Takayasu Arteritis

Xuesen Cheng1, Aimin Dang1, Naqiang Lv1

  • 1Department of Special Care Center, National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.

Journal of Atherosclerosis and Thrombosis
|December 18, 2018
PubMed
Abstract

Insights

Endothelial microparticles (EMPs) are elevated in patients with Takayasu arteritis (TA) and correlate with disease activity. These EMPs may serve as valuable biomarkers for assessing inflammation in TA.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biomarker Discovery

Background:

  • Takayasu arteritis (TA) is a chronic inflammatory condition affecting large arteries.
  • Endothelial dysfunction is a key feature of TA pathogenesis.
  • Microparticles (MPs) are cell-derived vesicles implicated in various inflammatory diseases.

Purpose of the Study:

  • To analyze microparticles (MPs) from endothelial cells (EMPs) and immune cells in healthy individuals and TA patients.
  • To investigate the relationship between MP levels and TA disease activity.

Main Methods:

  • Plasma samples from 32 TA patients and 19 healthy controls were analyzed using flow cytometry.
  • Antibodies against surface markers for endothelial cells (CD144), T cells (CD3), B cells (CD19), and monocytes (CD14) were employed.
  • Annexin V (Anx-V) staining was used to assess MP apoptosis.

Main Results:

  • Total EMPs, AnxV+ EMPs, and AnxV- EMPs were significantly increased in TA patients compared to controls.
  • Concentrations of EMPs were higher in active TA patients versus those in remission.
  • EMPs showed a positive correlation with TA disease activity, with specific associations noted for platelet counts and erythrocyte sedimentation rate.

Conclusions:

  • Elevated levels of endothelial microparticles are associated with inflammation in Takayasu arteritis.
  • EMPs show potential as useful biomarkers for monitoring TA disease activity.
  • Further research can explore the diagnostic and prognostic value of EMPs in TA.
Keywords:
Disease activityEndothelial cellsMicroparticleTakayasu arteritis

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