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Does Resting Motor Threshold Predict Motor Hand Recovery After Stroke?
Charlotte Rosso1,2, Jean-Charles Lamy1
1Institut du Cerveau et de la Moelle épinière, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France.
Frontiers in Neurology
|December 18, 2018
Summary
Resting Motor Threshold (rMT) shows a correlation with upper limb function after stroke, but its predictive power needs further study. This biomarker may be useful, though confounding factors require more investigation.
Area of Science:
- Neuroscience
- Rehabilitation Medicine
Background:
- Resting Motor Threshold (rMT) is a Transcranial Magnetic Stimulation (TMS) measurement indicating corticospinal excitability.
- Its potential as a biomarker for predicting post-stroke upper limb motor function is under investigation.
Purpose of the Study:
- To systematically review studies correlating rMT with upper limb motor function in stroke survivors.
- To assess the clinical significance of rMT as a predictor of motor recovery.
Main Methods:
- Systematic literature search for studies correlating rMT with upper limb motor function in stroke patients.
- Data extraction on correlations, time post-stroke, and stroke location.
- Evaluation of methodological quality using a published checklist.
Main Results:
- Eighteen studies (508 patients) were included; average quality score was 14.75/24.
- rMT correlated with motor function/dexterity in 68% of groups, explaining 31% of motor score variance.
- Correlation was consistent across early and chronic stroke stages.
Conclusions:
- A correlation between rMT and upper limb motor function post-stroke is frequently observed.
- It remains unclear if rMT is an independent predictor, considering confounding factors like age and stroke severity.
- Further research is necessary to establish rMT as a definitive biomarker for stroke recovery.
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