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Structure-Function Relationships of the Follicle-Stimulating Hormone Receptor.

Alfredo Ulloa-Aguirre1, Teresa Zariñán1, Eduardo Jardón-Valadez2

  • 1Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Frontiers in Endocrinology
|December 18, 2018
PubMed
Summary

The follicle-stimulating hormone receptor (FSHR) is vital for reproduction. This review details its structural features, focusing on how they regulate FSHR function, including ligand binding and signal transduction.

Keywords:
G protein-coupled receptor (GPCR)follicle-stimulating hormone receptor (FSHR)follitropin receptorglycoprotein hormone receptorsstructure

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Area of Science:

  • Reproductive Biology
  • Molecular Endocrinology
  • Cellular Signaling

Background:

  • The follicle-stimulating hormone receptor (FSHR) is a G-protein coupled receptor (GPCR) essential for reproductive processes.
  • It shares structural similarities with other glycoprotein hormone receptors, featuring an extensive extracellular domain for ligand binding and a transmembrane domain for signal transduction.

Purpose of the Study:

  • To review the key structural characteristics of the FSHR.
  • To elucidate how these structural features regulate FSHR function, encompassing trafficking, dimerization, ligand binding, activation, and signal transduction.

Main Methods:

  • This is a review article, synthesizing existing research on FSHR structure and function.
  • It focuses on analyzing the structural components and their roles in receptor regulation.

Main Results:

  • The FSHR's extracellular domain binds follicle-stimulating hormone (FSH).
  • The hinge region mediates ligand-stimulated activation.
  • The seven transmembrane domains and intracellular loops are critical for signal transmission and effector coupling.

Conclusions:

  • Understanding FSHR's structural intricacies is crucial for comprehending its regulatory mechanisms.
  • These structural insights are fundamental for reproductive biology and potential therapeutic interventions.