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Related Experiment Video

Updated: Jan 2, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Composite bijel-templated hydrogels for cell delivery.

Todd J Thorson1, Elliot L Botvinick2, Ali Mohraz1

  • 1Department of Chemical Engineering and Materials Science, University of California, Irvine, CA 92697, USA.

ACS Biomaterials Science & Engineering
|December 18, 2018
PubMed
Summary

Bicontinuous interfacially jammed emulsion gels (bijels) enable the creation of novel biomaterials for cell delivery. This templating method produces unique hydrogel composites with predictable structures for tissue engineering applications.

Keywords:
bijelcell deliverycompositemicrostructureself-assembly

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Soft Matter Physics

Background:

  • Conventional methods for creating porous biomaterials often lack architectural control.
  • Rapid prototyping techniques can be time-consuming and limited in micro-feature fabrication.
  • Bicontinuous interfacially jammed emulsion gels (bijels) offer a self-assembly approach for unique material structures.

Purpose of the Study:

  • To develop a novel templating method for creating biomaterials with controlled, interconnected porous architectures.
  • To synthesize fibrin-loaded polyethylene glycol hydrogel composites using bijel templating.
  • To demonstrate the efficacy of these composite bijel-templated hydrogels (CBiTHs) as a cell delivery system.

Main Methods:

  • Utilized kinetic arrest of spinodal decomposition in binary liquid systems to form bijels.
  • Introduced biocompatible precursors into bijels to create hydrogel scaffolds.
  • Synthesized fibrin-loaded polyethylene glycol hydrogel composites (CBiTHs).
  • Performed in vitro cell delivery studies using fluorescence-based tracking of normal human dermal fibroblasts.

Main Results:

  • Successfully templated hydrogel scaffolds with the morphological characteristics of parent bijels.
  • Demonstrated repeatable delivery of normal human dermal fibroblasts to acellular fibrin gels within CBiTHs.
  • Confirmed the structural uniqueness and cell delivery capability of the developed hydrogel composites.

Conclusions:

  • Bijel templating provides a robust and predictable method for synthesizing unique biomaterials for regenerative medicine.
  • Composite bijel-templated hydrogels (CBiTHs) represent a promising new platform for effective cell delivery.
  • This approach overcomes limitations of existing scaffold fabrication techniques, enabling advanced tissue engineering applications.