Related Experiment Video

Updated: Jan 31, 2026

Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent
06:46

Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent

Published on: May 8, 2017

9.3K

Selective MMP-13 Inhibitors: Promising Agents for the Therapy of Osteoarthritis

Yichao Wan1,2, Wei Li1,2, Zhipeng Liao1,2

  • 1Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China.

Current Medicinal Chemistry
|December 18, 2018
PubMed

Insights

Osteoarthritis (OA) treatment needs new drugs due to side effects of current options. Selective matrix metalloproteinase-13 (MMP-13) inhibitors show promise for OA therapy by targeting cartilage degradation.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Rheumatology

Background:

  • Osteoarthritis (OA) is a degenerative joint disease causing pain and cartilage damage.
  • Current OA treatments like NSAIDs and COX-2 inhibitors have cardiovascular risks.
  • Matrix metalloproteinase-13 (MMP-13) is crucial in OA cartilage degradation and is specifically expressed in patients.

Purpose of the Study:

  • To review recent advancements in selective MMP-13 inhibitors for OA treatment.
  • To explore both zinc-binding and non-zinc-binding MMP-13 inhibitor classes.

Main Methods:

  • Literature review of selective MMP-13 inhibitors.
  • Analysis of MMP-13's role in osteoarthritis pathogenesis.
  • Discussion of potential therapeutic strategies targeting MMP-13.

Main Results:

  • MMP-13 is a specific target for OA therapy.
  • Selective MMP-13 inhibition offers a potential alternative to broad-spectrum MMP inhibitors, avoiding musculoskeletal syndrome (MSS).
  • Two main classes of selective MMP-13 inhibitors have been identified: zinc-binding and non-zinc-binding.

Conclusions:

  • Selective MMP-13 inhibitors represent a promising therapeutic strategy for osteoarthritis.
  • Targeting MMP-13 specifically could overcome the limitations and side effects of current OA treatments.
  • Further research into these inhibitors may lead to novel OA therapies.
Keywords:
MMP-13Osteoarthritisarticular cartilageselective inhibitorsstructure-activity relationshipzinc-binding group.

More Related Videos

The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse09:26

The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse

Published on: May 16, 2016

37.8K
Methods for Rearing the Parasitoid Ganaspis brasiliensis, a Promising Biological Control Agent for the Invasive Drosophila suzukii07:56

Methods for Rearing the Parasitoid Ganaspis brasiliensis, a Promising Biological Control Agent for the Invasive Drosophila suzukii

Published on: June 2, 2022

4.9K

Related Concept Videos

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors01:19

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
576
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.0K
Carbon-13 (¹³C) NMR: Overview01:10

Carbon-13 (¹³C) NMR: Overview

Carbon-13 is a naturally occurring NMR-active isotope of carbon with a low natural abundance of 1.1%. In contrast, carbon-12 is the most abundant isotope of carbon with zero nuclear spin. Therefore, it is NMR inactive. The gyromagnetic ratio of carbon-13 is smaller than that of protons. As a result, carbon-13 resonance is about 6000 times weaker than proton resonance. For a given magnetic field strength, the resonance frequency of carbon-13 is about one-fourth of the resonance frequency for...
7.7K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
What is Natural Selection?01:32

What is Natural Selection?

Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
129.0K
Antibiotic Selection00:57

Antibiotic Selection

Overview
59.9K