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Narcolepsy, Precocious Puberty and Obesity in the Pediatric Population: a Literature Review

Ana Clara Maia Palhano1, Lenise Jihe Kim2, Gustavo A Moreira2

  • 1Faculdade de Medicina de Marília, Marília, São Paulo, Brazil.

Pediatric Endocrinology Reviews : PER
|December 18, 2018
PubMed

Insights

Narcolepsy in children is linked to endocrine issues like obesity and precocious puberty. Further research is needed to understand these complex associations and improve diagnosis.

Area of Science:

  • Pediatric Endocrinology
  • Sleep Medicine
  • Neurology

Background:

  • Narcolepsy is a sleep disorder with childhood onset.
  • Associations between narcolepsy and endocrine diseases (obesity, precocious puberty) are noted in children.
  • High incidence of overweight/obesity (25-74%) and precocious puberty (17%) in pediatric narcolepsy cases.

Purpose of the Study:

  • To review narcolepsy in pediatric populations.
  • To highlight diagnostic challenges in pediatric narcolepsy.
  • To explore mechanisms linking narcolepsy with precocious puberty and obesity.

Main Methods:

  • Literature review of studies on narcolepsy in children.
  • Analysis of reported associations with endocrine disorders.
  • Discussion of potential pathomechanisms.

Main Results:

  • Narcolepsy frequently co-occurs with obesity and precocious puberty in children.
  • Mechanisms underlying these associations remain unclear.
  • Diagnostic difficulties in pediatric narcolepsy are significant.

Conclusions:

  • Endocrine evaluation is crucial for children diagnosed with narcolepsy.
  • Understanding the link between narcolepsy and endocrine diseases is vital for comprehensive care.
  • Further research is required to elucidate the complex relationship.

Keywords:
MetabolismNarcolepsyObesityPrecocious Puberty

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