Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Binge Drinking's Effects on the Developing Brain-Animal Models.

Susanne Hiller-Sturmhöfel1, Linda Patia Spear1

  • 1Susanne Hiller-Sturmhöfel, Ph.D., is a science writer and editor affiliated with CSR Inc., Arlington, Virginia. Linda Patia Spear, Ph.D., is a distinguished professor, Department of Psychology, State University of New York, and the director of the Developmental Exposure Alcohol Research Center, Binghamton University, Binghamton, New York.

Alcohol Research : Current Reviews
|December 18, 2018
PubMed
Summary

Adolescent binge drinking can cause lasting cognitive deficits and behavioral changes. Animal studies show this exposure impacts brain development, potentially leading to anxiety and continued alcohol use into adulthood.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of age, sex, and handling on behavioral parameters in the multivariate concentric square field™ test.

Physiology & behavior·2020
Same author

Rats exposed to intermittent ethanol during late adolescence exhibit enhanced habitual behavior following reward devaluation.

Alcohol (Fayetteville, N.Y.)·2020
Same author

Timing Eclipses Amount: The Critical Importance of Intermittency in Alcohol Exposure Effects.

Alcoholism, clinical and experimental research·2020
Same author

Reflections: NIAAA's Directors Look Back on 25 Years.

Alcohol health and research world·2019
Same author

Visualizing Neural Pathways Affected by Alcohol in Animals.

Alcohol health and research world·2019
Same author

Genetic Engineering in Animal Models.

Alcohol health and research world·2019

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Addiction Research

Background:

  • Adolescence is a critical period for brain development.
  • Experimentation with substances, including alcohol, is common during adolescence.
  • Adolescent alcohol exposure may have long-term consequences due to ongoing brain maturation.

Purpose of the Study:

  • To investigate the long-term effects of adolescent intermittent ethanol exposure (AIE) on cognitive function, behavior, and brain alterations.
  • To understand how AIE influences the development of anxiety and alcohol-related phenotypes into adulthood.
  • To explore the underlying neurobiological mechanisms affected by adolescent binge drinking.

Main Methods:

  • Utilizing animal models, specifically the adolescent intermittent ethanol exposure (AIE) paradigm.

Related Experiment Videos

  • Assessing cognitive performance in challenging tasks.
  • Evaluating behavioral alterations such as risk preference, impulsivity, and anxiety-like behaviors.
  • Examining neurobiological changes including neurogenesis, inflammation, gene expression, and neurotransmitter systems.

    • Main Results:

    • AIE leads to cognitive deficits and behavioral changes like increased impulsivity and risk-taking.
    • Adolescents exposed to AIE exhibit heightened social and general anxiety in adulthood.
    • AIE can result in persistent alcohol-related phenotypes, such as reduced sensitivity to aversive effects and increased sensitivity to rewarding effects of alcohol.
    • Significant lasting alterations in the brain are observed, including reduced neurogenesis, increased proinflammatory responses, epigenetic changes, and altered neurotransmitter system activity.

    Conclusions:

    • Adolescent binge drinking has profound and lasting detrimental effects on brain development and function.
    • AIE in animal models provides valuable insights into the consequences of human adolescent alcohol use.
    • Understanding these neurobiological mechanisms is crucial for developing effective prevention and intervention strategies for adolescent alcohol misuse.