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Related Concept Videos

Autophagy01:27

Autophagy

5.9K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Related Experiment Video

Updated: Jan 31, 2026

Activating Autophagy by Aerobic Exercise in Mice
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Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

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Autophagy and ageing.

Hideaki Morishita, Noboru Mizushima

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |December 18, 2018
    PubMed
    Summary

    Autophagy, an essential cellular process, clears damaged components and is linked to longevity. Dysfunctional autophagy contributes to aging, while its activation promotes anti-aging effects.

    Area of Science:

    • Cellular Biology
    • Molecular Biology
    • Gerontology

    Background:

    • Autophagy is a fundamental intracellular degradation pathway involving lysosomes.
    • It prevents the buildup of damaged proteins and organelles, maintaining cellular health.
    • Dysfunctional autophagy is observed in aged cells and linked to age-related diseases.

    Purpose of the Study:

    • To review current understanding of autophagy's mechanisms and functions.
    • To explore the connection between autophagy and anti-aging processes.
    • To highlight recent advancements in autophagy research related to aging.

    Main Methods:

    • Literature review of existing research on autophagy.
    • Analysis of studies on genetic inhibition and activation of autophagy.

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    Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond
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    Related Experiment Videos

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  • Examination of data from long-lived model organisms.

    • Main Results:

    • Genetic inhibition of autophagy in mice results in aging-related diseases.
    • Autophagy is active in long-lived species, suggesting a role in longevity.
    • Evidence strongly supports autophagy's potent anti-aging properties.

    Conclusions:

    • Autophagy plays a crucial role in cellular homeostasis and combating aging.
    • Further research into autophagy mechanisms can inform strategies for healthy aging.
    • Targeting autophagy may offer therapeutic potential for age-related conditions.