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Aging and kidney disease.

Shu Wakino, Hiroshi Itoh

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |December 18, 2018
    PubMed
    Summary

    Aging accelerates chronic kidney disease (CKD) progression through cellular senescence. Targeting aging pathways offers novel therapeutic strategies for CKD patients, promoting successful aging.

    Area of Science:

    • Gerontology
    • Nephrology
    • Cellular Biology

    Background:

    • Kidney function declines with age, contributing to chronic kidney disease (CKD).
    • Cellular senescence and aging mechanisms, including telomere attrition and mitochondrial dysfunction, drive CKD initiation and progression.
    • Renal dysfunction also impacts the overall human aging process, creating a bidirectional relationship.

    Purpose of the Study:

    • To explore the intricate relationship between aging and chronic kidney disease (CKD).
    • To identify aging mechanisms influencing CKD pathogenesis and progression.
    • To investigate the potential of targeting aging pathways for novel CKD therapeutic strategies.

    Main Methods:

    • Review of mechanisms linking cellular senescence and organ aging to CKD.

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  • Analysis of interventions targeting aging pathways as therapeutic strategies for CKD.
  • Examination of aging phenotypes, such as frailty, as clinical markers for CKD prognosis.

    • Main Results:

    • Aging mechanisms like telomere attrition, genomic instability, and mitochondrial dysfunction are implicated in CKD.
    • Interventions targeting these aging pathways show therapeutic potential for CKD.
    • Aging phenotypes, including frailty, serve as prognostic markers for CKD, cardiovascular disease, and type II diabetes.

    Conclusions:

    • The aging process is closely intertwined with the development and progression of CKD.
    • Targeting aging mechanisms and ameliorating aging phenotypes represent a promising therapeutic avenue for CKD.
    • Promoting successful aging in CKD patients can be achieved by addressing these age-related pathways.