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Updated: Jan 31, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
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Age-related diseases of the skin and anti-aging medicine

Yoshikazu Yonei, Masamitsu Ichihashi, Wakako Takabe

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |December 18, 2018
    PubMed

    Insights

    Skin aging results from photo-aging (oxidative stress) and glycative stress. Understanding these processes, including advanced glycation end products (AGEs), can reveal new anti-aging treatments for skin rejuvenation.

    Area of Science:

    • Dermatology and anti-aging medicine.
    • Biochemistry of skin aging.

    Background:

    • Skin aging is assessed via wrinkles, spots, yellow tint, elasticity, and moisture.
    • Photo-aging (oxidative stress) and glycative stress are primary drivers of skin aging.

    Purpose of the Study:

    • To explore the roles of oxidative and glycative stress in skin aging.
    • To identify potential pathways for anti-aging treatments and skin rejuvenation.

    Main Methods:

    • Review of the mechanisms of oxidative and glycative stress on skin.
    • Analysis of how advanced glycation end products (AGEs) affect skin properties.

    Main Results:

    • Glycative stress leads to yellow tint and reduced skin elasticity due to AGEs and collagen cross-linking.
    • Oxidative stress causes dark spots via pigment formation and DNA damage, and wrinkles through matrix metalloproteinase (MMP) activation and collagen/elastin degeneration.

    Conclusions:

    • Oxidative and glycative stress are key factors in skin aging.
    • Targeting these stressors may offer effective anti-aging strategies for skin rejuvenation.

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