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Apatinib inhibits tumor growth and angiogenesis in PNET models

Shan Wu1,2, Jianjun Zhou2, Jing Guo3

  • 1College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, People's Republic of China.

Endocrine Connections
|December 18, 2018
PubMed

Insights

Apatinib shows promise for treating pancreatic neuroendocrine tumors (PNETs), comparable or superior to sunitinib. However, its efficacy is cell-type selective, potentially promoting metastasis in insulinomas.

Area of Science:

  • Oncology
  • Cancer Research
  • Pharmacology

Background:

  • Angiogenesis is crucial for pancreatic neuroendocrine tumor (PNET) growth and metastasis.
  • Apatinib, a KDR inhibitor, targets angiogenesis and is used for other cancers.
  • The efficacy of apatinib in PNETs requires investigation.

Purpose of the Study:

  • To compare the antitumor efficacy of apatinib with sunitinib in PNET models.
  • To evaluate apatinib's effects on angiogenesis and tumor cell cytotoxicity.
  • To assess apatinib's efficacy in subcutaneous and liver metastasis models of insulinoma and non-functional PNET.

Main Methods:

  • Utilized subcutaneous and liver metastasis models of insulinoma and non-functional PNET.
  • Administered apatinib and sunitinib to evaluate antitumor effects.
  • Assessed dose-dependency and tolerability of apatinib in mice.
  • Analyzed cell-type selectivity of apatinib in liver metastasis models.

Main Results:

  • Apatinib demonstrated comparable or superior antitumor effects to sunitinib in primary PNET.
  • Apatinib inhibited angiogenesis without direct tumor cell cytotoxicity.
  • Efficacy of apatinib in liver metastasis was cell-type selective.
  • Apatinib inhibited non-functional PNET metastasis but promoted insulinoma liver metastasis by inducing hypoxia.

Conclusions:

  • Apatinib shows potential for treating certain malignant PNETs.
  • Anti-angiogenesis therapy with apatinib may require careful consideration for benign insulinomas.
  • Further research is needed to understand apatinib's selective efficacy in PNETs.
Keywords:
KDRangiogenesisapatinibliver metastasispancreatic neuroendocrine tumors

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