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Expression Profiles of microRNAs in Drug-Resistant Non-Small Cell Lung Cancer Cell Lines Using microRNA Sequencing

Shousen Hu1, Yongliang Yuan2,3, Zhizhen Song2,3

  • 1Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
|December 18, 2018
PubMed
Abstract

Insights

This study identified microRNA (miRNA) expression profiles in drug-resistant non-small cell lung cancer (NSCLC) cell lines. Findings may reveal novel biomarkers and therapies for overcoming NSCLC drug resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Drug resistance is a significant challenge in non-small cell lung cancer (NSCLC) treatment.
  • Identifying molecular mechanisms of drug resistance is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate microRNA (miRNA) expression profiles in drug-resistant NSCLC cell lines.
  • To identify specific miRNAs associated with drug resistance in NSCLC.

Main Methods:

  • miRNA sequencing was employed to analyze miRNA expression in drug-resistant NSCLC cell lines.
  • Bioinformatic analyses were used to identify commonly dysregulated miRNAs and their pathways.
  • The Cancer Genome Atlas database was utilized for survival and ROC curve analyses.

Main Results:

  • A total of 29 upregulated and 36 downregulated miRNAs were identified in drug-resistant NSCLC cell lines.
  • Many dysregulated miRNAs were found to be involved in the Ras signaling pathway.
  • Several miRNAs, including hsa-mir-192 and hsa-mir-1293, were associated with lung cancer, with hsa-mir-1293 and hsa-mir-561 not directly linked to drug resistance.

Conclusions:

  • The identified miRNAs may serve as novel biomarkers for drug resistance in NSCLC.
  • These findings could lead to potential therapeutic strategies for overcoming drug resistance in NSCLC.
  • The study sheds light on potential mechanisms underlying drug resistance in non-small cell lung cancer.
Keywords:
Drug resistanceNon-small cell lung cancerhsa-mir-1293hsa-mir-561miRNAs

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