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Updated: Jan 31, 2026

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
Published on: November 23, 2013
Anti-N-methyl-D-aspartate receptor encephalitis: A case report
Hua Li1, Yan-Ke Guo1, Ying-Lin Cui1
1Department of Emergency, Henan Traditional Chinese Medicine Hospital, Zhengzhou, Henan.
Rationale:
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an auto-immune and paraneoplastic encephalitis with prominent neuropsychiatric manifestations. The N-methyl-D-aspartate receptor is located in the forebrain and hippocampus and plays a role in learning and memory.
Patient Concerns:
A 29-year-old female patient with anti-NMDAR encephalitis, was reported and we also reviewed the literature and summarised the characteristics of the cases.
Diagnoses:
In the present study, we reported 1 patient with anti-NMDAR encephalitis diagnosed by the detection of anti-NMDAR antibodies in serum and cerebrospinal fluid (CSF).
Interventions:
The patient received glucocorticoids and anti-epilepsy treatment as well as human immunoglobulin treatment.
Outcomes:
After treatment, the patient gradually regained consciousness and was discharged after 3 months of rehabilitation. At the follow-up 2 months later, the patient had the sequelae of memory impairment and limb movement disorders.
Lessons:
An accurate early diagnosis and active treatment are crucial to the improvement in the prognosis of patients with anti-NMDAR receptor encephalitis.
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