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Updated: Jan 31, 2026
10:19
High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
Published on: November 23, 2013
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Anti-N-methyl-D-aspartate receptor encephalitis: A case report
Hua Li1, Yan-Ke Guo1, Ying-Lin Cui1
1Department of Emergency, Henan Traditional Chinese Medicine Hospital, Zhengzhou, Henan.
Medicine
|December 19, 2018
Summary
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune disorder. Early diagnosis and treatment, including immunotherapy, are vital for improving patient outcomes and reducing long-term neurological deficits.
Area of Science:
- Neuroimmunology
- Neurology
Background:
- Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a severe autoimmune neurological disorder.
- It is characterized by prominent neuropsychiatric symptoms and affects the N-methyl-D-aspartate receptor in the forebrain and hippocampus, crucial for learning and memory.
Observation:
- A case report details a 29-year-old female patient diagnosed with anti-NMDAR encephalitis.
- Diagnosis was confirmed by detecting anti-NMDAR antibodies in serum and cerebrospinal fluid (CSF).
Findings:
- The patient underwent treatment with glucocorticoids, anti-epilepsy drugs, and human immunoglobulin therapy.
- Following treatment, the patient regained consciousness and was discharged after rehabilitation, but experienced residual memory and limb movement impairments.
Implications:
- This case underscores the importance of prompt diagnosis and aggressive treatment for anti-NMDAR encephalitis.
- Early intervention is critical for enhancing patient prognosis and minimizing long-term neurological sequelae.
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