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Rac GTPases in Hematological Malignancies.

Valerie Durand-Onaylı1, Theresa Haslauer2, Andrea Härzschel3

  • 1Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectious Disease, Rheumatology, Oncologic Center, Salzburg Cancer Research Institute-Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Cancer Cluster Salzburg, 5020 Salzburg, Austria. v.durand-onayli@salk.at.

International Journal of Molecular Sciences
|December 19, 2018
PubMed
Summary

Deregulation of Rac GTPases, key regulators of the cytoskeleton, contributes to hematologic malignancies. Understanding their role in cell migration and survival is crucial for developing new treatments for leukemia and lymphoma.

Keywords:
Rac GTPasescancerleukemialymphomamicroenvironmentmigrationproliferationsurvival

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