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Updated: Jan 31, 2026
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Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica
Published on: October 28, 2022
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Association between Plasma HMGB-1 and Silicosis: A Case-Control Study.
Jixuan Ma1,2, Yun Zhou3,4, Wei Li5,6
1Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. majixuan@hust.edu.cn.
International Journal of Molecular Sciences
|December 19, 2018
Summary
Elevated High-mobility group box-1 (HMGB-1) levels in plasma are linked to silicosis. This study found higher HMGB-1 concentrations in silicosis patients, suggesting it may be a biomarker for this fibrotic lung disease.
Area of Science:
- Pulmonary Medicine
- Biomarkers
- Occupational Health
Background:
- High-mobility group box-1 (HMGB-1) is implicated in fibrotic diseases.
- The specific role of HMGB-1 in silicosis remains unclear.
Purpose of the Study:
- To investigate the association between plasma High-mobility group box-1 (HMGB-1) concentrations and silicosis.
- To evaluate HMGB-1 as a potential diagnostic biomarker for silicosis.
Main Methods:
- A case-control study was conducted with 74 silicosis patients and 107 healthy controls in China.
- Plasma HMGB-1 levels were measured using Enzyme-linked immunosorbent assay (ELISA).
- Logistic regression and Receiver Operating Characteristic (ROC) curve analyses were employed.
Main Results:
- Plasma HMGB-1 concentrations were significantly higher in silicosis patients compared to healthy controls (p < 0.05).
- Increased HMGB-1 levels were positively associated with higher odds of silicosis (OR = 1.86 per 1 ng/mL increase).
- ROC analysis indicated that plasma HMGB-1 >7.419 ng/mL had 81.6% sensitivity and 80.4% specificity for silicosis (AUC = 0.84).
Conclusions:
- Elevated plasma HMGB-1 is positively associated with an increased risk of silicosis.
- HMGB-1 may serve as a valuable biomarker for the diagnosis of silicosis.
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