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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
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Isavuconazole in the Treatment of Coccidioidal Meningitis

Arash Heidari1,2, Miriam Quinlan1, David J Benjamin3

  • 1Kern County Medical Center, Bakersfield, California, USA.

Antimicrobial Agents and Chemotherapy
|December 19, 2018
PubMed

Insights

Lifelong antifungal therapy is needed for coccidioidal meningitis. Isavuconazole showed success in treating three patients and stabilizing disease in six, suggesting it as a valuable option for this fungal infection.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Pharmacology

Background:

  • Coccidioidal meningitis necessitates long-term antifungal treatment.
  • Treatment challenges include cumulative toxicity and limited antifungal efficacy.
  • Salvage therapy is required for some patients.

Purpose of the Study:

  • To evaluate the efficacy and safety of isavuconazole as a salvage therapy for coccidioidal meningitis.
  • To assess the role of isavuconazole in managing refractory cases of coccidioidal meningitis.

Main Methods:

  • Retrospective review of nine patients with coccidioidal meningitis.
  • Patients were treated with isavuconazole.
  • Outcomes including treatment success and disease stability were analyzed.

Main Results:

  • Isavuconazole treatment resulted in successful therapy in three out of nine patients.
  • Stable disease was observed in six out of nine patients.
  • No major adverse events were reported in the abstract.

Conclusions:

  • Isavuconazole demonstrates potential as an effective salvage therapy for coccidioidal meningitis.
  • It represents a promising addition to the current therapeutic armamentarium for this serious fungal infection.
  • Further prospective studies are warranted to confirm these findings.
Keywords:
coccidioidesisavuconazolemeningitis

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