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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

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Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species

José F Muñoz1, Lalitha Gade2, Nancy A Chow2

  • 1Broad Institute of MIT and Harvard, Cambridge, MA, 02144, USA.

Nature Communications
|December 19, 2018
PubMed

Insights

The study analyzes the genomes of the emerging multidrug-resistant fungus Candida auris and related species. It identifies key genes associated with drug resistance and virulence, offering insights into C. auris

Area of Science:

  • Mycology
  • Genomics
  • Infectious Diseases

Background:

  • Candida auris is an emerging multidrug-resistant fungal pathogen causing global outbreaks.
  • C. auris is closely related to rarely observed, multidrug-resistant species within the C. haemulonii clade.

Purpose of the Study:

  • To perform a comprehensive genomic analysis of C. auris clades and related species.
  • To identify genetic factors contributing to drug resistance and virulence in C. auris.

Main Methods:

  • Analysis of near-complete genome assemblies for four C. auris clades and three related species.
  • RNA-Seq-guided gene prediction to identify conserved and species-specific genes.
  • Comparative genomics to map chromosomal rearrangements and identify genetic variations.

Main Results:

  • Most mating and meiosis genes are conserved across clades, with distinct mating loci (MTLa or MTLα).
  • Identified expanded gene families (transporters, lipases) and variations (ERG11 mutations, copy number variants) linked to drug resistance and virulence.
  • Discovered C. auris-specific and conserved transporters and metabolic regulators potentially influencing drug response.

Conclusions:

  • Genomic insights into C. auris provide a foundation for understanding its emergence and spread.
  • Identification of drug resistance and virulence genes can inform therapeutic strategies against C. auris infections.

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